Custom Peptides
Cayman Chemical MethoxphenIdInhydrochLRId 10mg
An analog of diphenidine featuring a methoxy group at the two position of a phenyl group
Cayman Chemical PB22 N 5hydroxypentyl3c 10mg
A potential metabolite of PB-22; intended for forensic and research purposes
Cayman Chemical Daclatsvr 10mg
An NS5A inhibitor (Kds = 8 and 210 nM for the NS5A33-202 and NS5A26-202 residues of HCV genotype 1b, respectively); potently inhibits HCV replication in multiple HCV replicon genotypes (EC50s = 9-146 pM) with the highest potency in genotypes 1b and 4a (EC50s = 9 and 12 pM, respectively); disrupts NS5A subcellular localization when used at a concentration of 1 nM; inhibits HCV RNA synthesis and virion assembly and secretion when used at a concentration of 1 nM; inhibits OAT1B1 and OAT1B3 (IC50s = 1.5 and 3.27 µM, respectively)
Cayman Chemical sorentn 10mg
A flavonoid with diverse biological activities; induces apoptosis in and reduces cell viability of PATU-8988 and PANC-1 pancreatic cancer cells; reduces expression of COX-2, IL-6, 5-LO, and TNF-α in RAW 264.7 cells; reduces carrageenan-induced paw edema and air pouch blood vessel swelling in mice at 20 mg/kg; increases stomach levels of SOD and GSH and reduces ulcer area in a rat model of indomethacin-induced gastric ulcers
Cayman Chemical ElagolIxsodIum salt 10mg
An antagonist of GnRHR (Ki = 0.9 nM in a radioligand binding assay); selective for GnRHR over CYP3A4 (IC50 = 56 μM) as well as a panel of 100 receptors, ion channels, enzymes, and transporters (IC50s = >10 μM); inhibits GnRH-induced inositol phosphate production in RBL-1 cells expressing human GnRHR (IC50 = 1.5 nM); suppresses production of luteinizing hormone in castrated male cynomolgus macaques at 30 mg/kg
Cayman Chemical ToyocamycInhydrate 10mg
A natural adenosine analog that prevents IRE1α-induced mRNA cleavage (IC50 = 80 nM) and inhibits constitutive activation of XBP1 in multiple myeloma cell lines; used to study IRE1α action in the endoplasmic reticulum stress response
Cayman Chemical zngbr offIcnle 6Gngerol 10mg
A natural chemical found in fresh ginger that activates TRPV1 (EC50 = 3.3 µM) as well as the TRP ankyrin receptor TRPA1 (EC50 = 10.4 µM)
Cayman Chemical CrIdnImododIum salt 10mg
An inducer of type I interferon production; induces IRF3 phosphorylation, IFN-β production, and NF-κB activation in wild-type, but not in STING mutant, murine macrophages; increases plasma levels of IFN in weanling and adult mice from 112-1,792 mg/kg; protects against viral infection in mouse models of Semliki forest, coxsackie B1, Columbia SK, herpes, and pseudorabies viruses (PD50s = 17-320 mg/kg); increases uterine expression of estrogen and progesterone receptors in ovariectomized rats; reverses tamoxifen-induced decreases in progesterone receptor expression in young rats
Cayman Chemical TrIgonlaDIoscIn 10mg
A natural steroid saponin that inhibits proliferation and induces apoptosis in cancer cells; has antioxidant activity and induces autophagy
Cayman Chemical -EtomoxIrsodIum salt 10mg
An inhibitor of CPT1; inhibits fatty acid transport into the mitochondria for β-oxidation; inhibits fatty acid oxidation in hepatocytes in vitro (IC50s = 0.1, 1, and 10 µM for human, guinea pig, and rat hepatocytes, respectively); decreases ATP-linked and uncoupled oxygen consumption in C2C12 myotubes when used in combination with BPTES or UK 5099
Cayman Chemical S-AdenosylhomocysteIn 10mg
An amino acid derivative and an intermediate, by-product, or modulator of several metabolic pathways, including the activated methyl cycle and cysteine biosynthesis; also a product of SAM-dependent methylation of biological molecules, including DNA, RNA, and histones, and other proteins
Cayman Chemical MethylpIperIdIno pyrazole 10mg
A highly selective ERα receptor antagonist (Ki = 5.6 nM; IC50 = 80 nM)
Cayman Chemical Cyproconazole 10mg
A triazole fungicide; reduces mycelial growth of A. mellea on grapevine roots; reduces defoliation of rose plants induced by D. rosae; Lethal to C. riparius and D. tigrina (LC50s = 17.46 and 47.38 mg/L in tank water, respectively); induces liver hypertrophy and fat vacuolation, as well as induces hepatocellular adenoma and carcinoma formation, in mice
Cayman Chemical LevetIracetam 10mg
An antiepileptic agent; binds to the synaptic vesicle protein SV2A (IC50 = 1.99 μM); suppresses seizures in fully kindled rats