Custom Peptides
Cayman Chemical VUF8430hydrobromIde 10mg
A histamine H4 receptor agonist (Ki = 31.6 nM); selective for histamine H4 over H1 and H3 receptors in radioligand binding assays (Kis = >1 and 1 µM, respectively) and is less active in isolated guinea pig atria, which endogenously expresses high levels of H2 receptors (pD2 = 3.8); inhibits forskolin-induced, cAMP-mediated increases in β-galactosidase activity (EC50 = 50.1 nM); enhances HCl-induced formation of gastric lesions in rats at 30 mg/kg; reduces mechanical and thermal allodynia in a mouse model of SNI-induced peripheral neuropathy
Cayman Chemical BIcuculIn methochlorIde 10mg
An enantiomer of (+)-bicuculline methochloride; increases the firing rate in rat cortical neurons similar to the (+) isomer, but lacks GABA antagonist activity; inhibits sodium-independent GABA receptor binding (IC50 = 500 μM), which is approximately 100-fold less potent than the (+) isomer, but there is no stereoselectivity for sodium-dependent GABA receptor binding
Cayman Chemical RW3trIfluoroacetate salt 10mg
An antimicrobial peptide; active against E. coli and S. aureus (IC50s = 16 and 8 µM, respectively); induces hemolysis of isolated ovine erythrocytes
Cayman Chemical ImeglImInhydrochlorIde 10mg
An anti-hyperglycemic compound; inhibits high-glucose- or tert-butyl hydroperoxide-induced cell death in HMEC-1 cells at 100 µM; reduces tert-butyl hydroperoxide-induced cytochrome c levels, as well as mitochondrial membrane permeability without affecting mitochondrial respiration, in HMEC-1 cells at 100 µM; decreases plasma glucose levels and increases plasma insulin levels in a rat model of high-fat diet-induced obesity at 150 mg/kg in the diet; reduces colonic balloon-induced pain-related muscle contractions in rats at 100 mg/kg; reduces colonic hyperpermeability in a rat model of LPS-induced IBS at 100 mg/kg
Cayman Chemical PRfluoroheptnsulfonIc ACD 10mg
A perfluoroalkyl substance; induces malformations in zebrafish larvae (EC50 = 168.1 µM); has been found in landfill leachate; prenatal exposure to PFHpS is associated with decreased birth weight
Cayman Chemical BIotInH10trIfluoroacetAT 10mg
A biotinylated form of H10; has been used in ELISA and co-immunoprecipitation assays to assess AGR2 levels in cancer cells
Cayman Chemical SB-200646hydrochlorIde 10mg
A dual antagonist of 5-HT2C (Ki = 125 nM in isolated rat cortex) and 5-HT2B receptors (pA2 = 7.5 in rat stomach fundus preparations); selective for 5-HT2C and 5-HT2B over 5-HT1A, 5-HT2A, 5-HT1D, 5-HT3, benzodiazepine, GABAA, α1-, α2A-, α2B-, β1-, and β2-adrenergic, dopamine D1 and D2, and histamine H1 receptors (Kis = >10 µM for all); reverses mCPP-induced hypophagia and decreases in social interaction time in rats at 20 and 40 mg/kg
Cayman Chemical SuprafenacIn 10mg
An inhibitor of tubulin polymerization (IC50 = 0.38 μM) with anticancer activit; inhibits the proliferation of HeLa, Jurkat, SNU-16, MDA-MB-231, A549, SH-SY5Y, HCT15, and KB-3-1 cells (IC50s = 83-381.2 nM) and P-glycoprotein-enriched KB-VI cells (IC50 = 215.7 nM); increases phosphorylation of JNK and Bcl-2 and induces apoptosis and cell cycle arrest at the G2/M phase in HeLa cells at 10 μM; reduces tumor growth in an HCT15 colon adenocarcinoma mouse xenograft model at 20 mg/kg
Cayman Chemical Magnla bond Galgravn 10mg
A lignan with diverse biological activities; inhibits the binding of PAF to isolated rabbit platelet plasma membranes (IC50 = 4.5 µM); inhibits RANKL- and M-CSF-induced osteoclast formation in mouse bone marrow-derived macrophages at 3-100 µM; protects against cytotoxicity induced by human Aβ (25-35) in primary rat hippocampal neurons at 10 µM; reduces acetic acid-induced abdominal constrictions in mice and carrageenan-induced paw edema in rats at 20 mg/kg
Cayman Chemical PolysarcosIn20 10mg
An amine-functionalized hydrophilic polymer; addition to surface-grafted polymer brushes reduces protein absorption and mammalian and bacterial cell attachment
Cayman Chemical S7trIfluoroacetate salt 10mg
A peptide antagonist of the IL-6 receptor; inhibits IL-6 binding to the IL-6 receptor in a concentration-dependent manner; inhibits IL-6-induced increases in VEGF levels in C-33 A cells and RPMI-8226 B cell lymphocytes at 50 µM; reduces tumor volume in an IL-6-overexpressing C-33 A cervical cancer mouse xenograft at 50 mg/kg every two days; increases LNP glioma targeting and increases survival in a U251 glioblastoma mouse xenograft model when coupled to cysteine and LNP surfaces
Cayman Chemical CID-44216842 10mg
A Cdc42 inhibitor; inhibits GTP binding to wild-type Cdc42 and Cdc42Q61L (EC50s = 0.3 and 0.5 µM, respectively)
Cayman Chemical 1 2DImyrIstoyld54snglycer 10mg
An internal standard for the quantification of 1,2-dimyristoyl-sn-glycero-3-PC by GC- or LC-MS
Cayman Chemical Palovaroten 10mg
An orally bioavailable RARγ agonist; increases RARE activity and decreases IL-1β-induced NF-κB activity in primary mouse stromal cells at 60 nM; inhibits activin A-induced chondrogenic and osteogenic differentiation of mouse FAPs expressing ACVR1R206H at 10 nM; inhibits heterotopic ossification and preserves limb movement and growth in a ACVR1R206H FOP mouse model; decreases heterotopic ossification by 50 to 60% in a rat model of traumatic blast injury at 1 mg/kg per day for 14 days
Cayman Chemical ZK 756326hydrochlorIde 10mg
A non-peptide agonist of CCR8; inhibits binding of CCL1 to human CCR8 (IC50 = 1.8 µM); stimulates extracellular acidification in cells expressing human and mouse CCR8 (EC50s = 254 nM and 2.6 µM, respectively); exhibits >28-fold selectivity for CCR8 over 26 other GPCRs; binds to the serotonergic receptors 5-HT1A, 5-HT2B, 5-HT2C, and 5-HT5A (IC50s = 5.4, 4.4, 34.8, and 16 µM, respectively); induces Gαi-mediated calcium mobilization, ERK phosphorylation, exhibits leukocyte chemotactic activity, and inhibits HIV fusion of cells expressing CD4 and CCR8